Papakrivopoulou, E;
Dean, CH;
Copp, AJ;
Long, DA;
(2014)
Planar cell polarity and the kidney.
Nephrol Dial Transplant
, 29
(7)
pp. 1320-1326.
10.1093/ndt/gft484.
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Abstract
Planar cell polarity (PCP) is the uniform orientation and alignment of a group of cells orthogonal to the apical-basal axis within a tissue. Originally described in insects, it is now known that PCP is required for many processes in vertebrates, including directional cell movement, polarized cell division, ciliary orientation, neural tube closure, heart development and lung branching. In this review, we outline the evidence implicating PCP in kidney development and disease focusing initially on the function of PCP in ureteric bud branching and elongation. We then describe how defects in PCP may lead to polycystic kidney disease and discuss a newly identified role for PCP in the kidney filtration barrier.
| Type: | Article |
|---|---|
| Title: | Planar cell polarity and the kidney. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ndt/gft484 |
| Publisher version: | http://dx.doi.org/10.1093/ndt/gft484 |
| Additional information: | © The Author 2013. Published by Oxford University Press on behalf of ERAEDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/3.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| Keywords: | cell alignment, glomerular filtration barrier, kidney development, polycystic kidney disease, ureteric bud branching |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1418749 |
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