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A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease

Papapetropoulos, S; Katzen, H; Schrag, A; Singer, C; Scanlon, BK; Nation, D; Guevara, A; (2008) A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease. BMC Neurology , 8 , Article 21. 10.1186/1471-2377-8-21. Green open access

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Abstract

Background: Hallucinations occur in 20-40% of PD patients and have been associated with unfavorable clinical outcomes (i.e., nursing home placement, increased mortality). Hallucinations, like other non-motor features of PD, are not well recognized in routine primary/secondary clinical practice. So far, there has been no instrument for uniform characterization of hallucinations in PD. To this end, we developed the University of Miami Parkinson's disease Hallucinations Questionnaire (UM-PDHQ) that allows comprehensive assessment of hallucinations in clinical or research settings.Methods: The UM-PDHQ is composed of 6 quantitative and 14 qualitative items. For our study PD patients of all ages and in all stages of the disease were recruited over an 18-month period. The UPDRS, MMSE, and Beck Depression and Anxiety Inventories were used for comparisons.Results and Discussion: Seventy consecutive PD patients were included in the analyses. Thirty-one (44.3%) were classified as hallucinators and 39 as non-hallucinators. No significant group differences were observed in terms of demographics, disease characteristics, stage, education, depressive/anxiety scores or cognitive functioning (MMSE) between hallucinators and non-hallucinators. Single mode hallucinations were reported in 20/31 (visual/14, auditory/4, olfactory/2) whereas multiple modalities were reported in 11/31 patients. The most common hallucinatory experience was a whole person followed by small animals, insects and reptiles.Conclusion: Using the UM-PDHQ, we were able to define the key characteristics of hallucinations in PD in our cohort. Future directions include the validation of the quantitative part of the questionnaire than will serve as a rating scale for severity of hallucinations.

Type: Article
Title: A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2377-8-21
Publisher version: http://dx.doi.org/10.1186/1471-2377-8-21
Language: English
Additional information: © 2008 Papapetropoulos et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: BECK DEPRESSION INVENTORY, VISUAL HALLUCINATIONS, AUDITORY HALLUCINATIONS, PSYCHOTIC SYMPTOMS, RATING-SCALE, RISK-FACTORS, DEMENTIA, PHENOMENOLOGY, MULTICENTER, PREVALENCE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/141866
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