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Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study

Widschwendter, M; Apostolidou, S; Raum, E; Rothenbacher, D; Fiegl, H; Menon, U; Stegmaier, C; ... Brenner, H; + view all (2008) Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study. PLoS ONE , 3 (7) , Article e2656. 10.1371/journal.pone.0002656. Green open access

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Abstract

Epigenetic changes are emerging as one of the most important events in carcinogenesis. Two alterations in the pattern of DNA methylation in breast cancer (BC) have been previously reported; active estrogen receptor-α (ER-α) is associated with decreased methylation of ER-α target (ERT) genes, and polycomb group target (PCGT) genes are more likely than other genes to have promoter DNA hypermethylation in cancer. However, whether DNA methylation in normal unrelated cells is associated with BC risk and whether these imprints can be related to factors which can be modified by the environment, is unclear.

Type: Article
Title: Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0002656
Publisher version: http://dx.doi.org/10.1371/journal.pone.0002656
Language: English
Additional information: © 2008 Widschwendter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The work described in this manuscript was supported by The Eve Appeal and The Oak Foundation and grants from the European Union and the FWF Austrian Science Fund (awarded to M. Widschwendter) and by a grant from the Baden-Württemberg Ministry of Research, Science and Arts (awarded to H. Brenner). The funders did not play any role in the design or conduct of the study.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/141828
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