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A systematic review of definitions of extreme phenotypes of HIV control and progression.

Gurdasani, D; Iles, L; Dillon, DG; Young, EH; Olson, AD; Naranbhai, V; Fidler, S; ... on behalf of the UK HIV Genomics Consortium, ; + view all (2014) A systematic review of definitions of extreme phenotypes of HIV control and progression. AIDS , 28 (2) pp. 149-162. 10.1097/QAD.0000000000000049. Green open access

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Abstract

The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.

Type: Article
Title: A systematic review of definitions of extreme phenotypes of HIV control and progression.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/QAD.0000000000000049
Publisher version: http://dx.doi.org/10.1097/QAD.0000000000000049
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1418210
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