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Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.

Youziel, J; Akhbar, AR; Aziz, Q; Smith, ME; Caddick, S; Tinker, A; Baker, JR; (2014) Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Org Biomol Chem , 12 (4) pp. 557-560. 10.1039/c3ob42141d. Green open access

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Abstract

Bromo- and thiomaleimides are shown to serve as highly effective quenchers of a covalently attached fluorophore. Reactions with thiols that lead to removal of the maleimide conjugation, or detachment of the fluorophore from the maleimide, result in 'turn-on' of the fluorescence. These reagents thus offer opportunities in thiol sensing and intracellular reporting.

Type: Article
Title: Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c3ob42141d
Publisher version: http://dx.doi.org/10.1039/c3ob42141d
Additional information: © The Royal Society of Chemistry 2014. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1417807
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