Kotiadis, VN;
Duchen, MR;
Osellame, LD;
(2014)
Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health.
Biochim Biophys Acta
, 1840
(4)
pp. 1254-1265.
10.1016/j.bbagen.2013.10.041.
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Abstract
The maintenance of cell metabolism and homeostasis are fundamental characteristics of living organisms. In eukaryotes, mitochondria are the cornerstone of these life supporting processes, playing leading roles in a host of core cellular functions, including energy transduction, metabolic and calcium signalling, and supporting roles in a number of biosynthetic pathways. The possession of a discrete mitochondrial genome dictates that the maintenance of mitochondrial 'fitness' requires quality control mechanisms which involve close communication with the nucleus.
| Type: | Article |
|---|---|
| Title: | Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bbagen.2013.10.041 |
| Publisher version: | http://dx.doi.org/10.1016/j.bbagen.2013.10.041 |
| Additional information: | © 2013 The Authors. Published by Elsevier B.V. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Antioxidant Defence, Mitochondria, Mitophagy, Protein Homeostasis, Quality Control, Retrograde Signalling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1417548 |
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