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Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current

Savtchenko, LP; Rusakov, DA; (2014) Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current. Philosophical transactions of the Royal Society of London. Series B, Biological sciences , 369 (1633) , Article 20130167. 10.1098/rstb.2013.0167. Green open access

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Abstract

The prevailing view at present is that postsynaptic expression of the classical NMDA receptor-dependent long-term potentiation relies on an increase in the numbers of local AMPA receptors (AMPARs). This is thought to parallel an expansion of postsynaptic cell specializations, for instance dendritic spine heads, which accommodate synaptic receptor proteins. However, glutamate released into the synaptic cleft can normally activate only a hotspot of low-affinity AMPARs that occur in the vicinity of the release site. How the enlargement of the AMPAR pool is causally related to the potentiated AMPAR current remains therefore poorly understood. To understand possible scenarios of postsynaptic potentiation, here we explore a detailed Monte Carlo model of the typical small excitatory synapse. Simulations suggest that approximately 50% increase in the synaptic AMPAR current could be provided by expanding the existing AMPAR pool at the expense of 100-200% new AMPARs added at the same packing density. Alternatively, reducing the inter-receptor distances by only 30-35% could achieve a similar level of current potentiation without any changes in the receptor numbers. The NMDA receptor current also appears sensitive to the NMDA receptor crowding. Our observations provide a quantitative framework for understanding the 'resource-efficient' ways to enact use-dependent changes in the architecture of central synapses.

Type: Article
Title: Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current
Location: England
Identifier: PMCID: PMC3843895
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rstb.2013.0167
Publisher version: http://dx.doi.org/10.1098/rstb.2013.0167
Language: English
Additional information: © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: AMPA receptor, NMDA receptor, Long-term potentiation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1417450
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