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Maternal infection and risk of intrapartum death: a population based observational study in South Asia.

Iwamoto, A; Seward, N; Prost, A; Ellis, M; Copas, A; Fottrell, E; Azad, K; ... Costello, A; + view all (2013) Maternal infection and risk of intrapartum death: a population based observational study in South Asia. BMC Pregnancy Childbirth , 13 (1) , Article 245. 10.1186/1471-2393-13-245. Green open access

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Abstract

Approximately 1.2 million stillbirths occur in the intrapartum period, and a further 717,000 annual neonatal deaths are caused by intrapartum events, most of which occur in resource poor settings. We aim to test the 'double-hit' hypothesis that maternal infection in the perinatal period predisposes to neurodevelopmental sequelae from an intrapartum asphyxia insult, increasing the likelihood of an early neonatal death compared with asphyxia alone. This is an observational study of singleton newborn infants with signs of intrapartum asphyxia that uses data from three previously conducted cluster randomized controlled trials taking place in rural Bangladesh and India.

Type: Article
Title: Maternal infection and risk of intrapartum death: a population based observational study in South Asia.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2393-13-245
Publisher version: http://dx.doi.org/10.1186/1471-2393-13-245
Additional information: © 2013 Iwamoto et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Maternal infection; Double hit hypothesis; Intrapartum-related neonatal death; Prolonged rupture of membranes; Neonatal mortality; Low-income countries; Resource-poor;
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
UCL > Provost and Vice Provost Offices > VP: Research
URI: https://discovery.ucl.ac.uk/id/eprint/1417275
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