Ohnmacht, SA;
Varavipour, E;
Nanjunda, R;
Pazitna, I;
Di Vita, G;
Gunaratnam, M;
Kumar, A;
... Neidle, S; + view all
(2014)
Discovery of new G-quadruplex binding chemotypes.
Chem Commun (Camb)
(8)
pp. 893-1032.
10.1039/c3cc48616h.
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Abstract
We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
| Type: | Article |
|---|---|
| Title: | Discovery of new G-quadruplex binding chemotypes. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c3cc48616h |
| Publisher version: | http://dx.doi.org/10.1039/c3cc48616h |
| Additional information: | © The Royal Society of Chemistry 2014. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1416477 |
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