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Immediate antiretroviral therapy in young HIV-infected children: benefits and risks.

Collins, IJ; Judd, A; Gibb, DM; (2014) Immediate antiretroviral therapy in young HIV-infected children: benefits and risks. Curr Opin HIV AIDS , 9 (1) pp. 87-94. 10.1097/COH.0000000000000027. Green open access

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Abstract

Recent WHO guidelines recommend immediate initiation of lifelong antiretroviral therapy (ART) in all children below 5 years, irrespective of immune/clinical status, to improve access to paediatric ART. Interim trial results provide strong evidence for immediate ART during infancy because of high short-term risk of mortality and disease progression, but there is wider debate regarding the potential risks and benefits of immediate ART in asymptomatic children aged above 1 year. Concerns include long-term toxicities and treatment failure, particularly in resource-constrained settings with limited paediatric treatment options.

Type: Article
Title: Immediate antiretroviral therapy in young HIV-infected children: benefits and risks.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/COH.0000000000000027
Publisher version: http://dx.doi.org/10.1097/COH.0000000000000027
Additional information: © 2014 Lippincott Williams & Wilkins, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1416380
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