Collins, IJ;
Judd, A;
Gibb, DM;
(2014)
Immediate antiretroviral therapy in young HIV-infected children: benefits and risks.
Curr Opin HIV AIDS
, 9
(1)
pp. 87-94.
10.1097/COH.0000000000000027.
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Abstract
Recent WHO guidelines recommend immediate initiation of lifelong antiretroviral therapy (ART) in all children below 5 years, irrespective of immune/clinical status, to improve access to paediatric ART. Interim trial results provide strong evidence for immediate ART during infancy because of high short-term risk of mortality and disease progression, but there is wider debate regarding the potential risks and benefits of immediate ART in asymptomatic children aged above 1 year. Concerns include long-term toxicities and treatment failure, particularly in resource-constrained settings with limited paediatric treatment options.
| Type: | Article |
|---|---|
| Title: | Immediate antiretroviral therapy in young HIV-infected children: benefits and risks. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/COH.0000000000000027 |
| Publisher version: | http://dx.doi.org/10.1097/COH.0000000000000027 |
| Additional information: | © 2014 Lippincott Williams & Wilkins, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1416380 |
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