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Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes

Hughes, AD; Bathula, R; Park, C; Tillin, T; Wit, N; McG Thom, S; Chaturvedi, N; (2013) Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes. PLoS One , 8 (10) , Article e76680. 10.1371/journal.pone.0076680. Green open access

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Abstract

People of South Asian descent have an increased risk of cardiovascular disease (CVD) and diabetes, but little is known about the microcirculation in South Asian people despite evidence that this plays an important role in the aetiology of CVD. We compared the retinal microcirculation in a population-based sample of 287 middle-aged adults (144 European 143 South Asian) matched for age and sex. Retinal photographs were taken and analysed using a validated semi-automated program and microvascular measures were compared. Blood pressure, anthropometry and fasting bloods were also measured. South Asians had significantly fewer arteriolar and venular vessels and bifurcations. Arterioles and venules were longer and venules were also more tortuous in South Asians. These differences were not explained by adjustment for traditional risk factors including blood pressure, body mass index, diabetes or measures of insulin resistance. People of South Asian descent have rarefaction of the retinal microcirculation compared to age-sex matched individuals of European descent. Reduced microvascular density could contribute to the elevated risk of CVD and impaired glucose tolerance in South Asian people.

Type: Article
Title: Microcirculatory rarefaction in South Asians - a potential mechanism for increased cardiovascular risk and diabetes
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0076680
Publisher version: http://dx.doi.org/10.1371/journal.pone.0076680
Language: English
Additional information: © 2013 Hughes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3792020
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/1416220
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