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Multimodality characterization of microstructure by the combination of diffusion NMR and time-domain diffuse optical data

Proverbio, A; Siow, BM; Lythgoe, MF; Alexander, DC; Gibson, AP; (2014) Multimodality characterization of microstructure by the combination of diffusion NMR and time-domain diffuse optical data. Phys Med Bio , 59 (11) 2639 - 2658. 10.1088/0031-9155/59/11/2639. Green open access

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Abstract

Combining datasets with a model of the underlying physics prior to mapping of tissue provides a novel approach improving the estimation of parameters. We demonstrate this approach by merging near infrared diffuse optical signal data with diffusion NMR data to inform a model describing the microstructure of a sample. The study is conducted on a homogeneous emulsion of oil in a dispersion medium of water and proteins. The use of a protein based background, rich in collagen, introduces a similarity to real tissues compared to other models such as intralipids. The sample is investigated with the two modalities separately. Then, the two datasets are used to inform a combined model, and to estimate the size of the microstructural elements and the volume fraction. The combined model fits the microstructural properties by minimizing the difference between experimental and modelled data. The experimental results are validated with confocal laser scanning microscopy. The final results demonstrate that the combined model provides improved estimates of microstructural parameters compared to either individual model alone.

Type: Article
Title: Multimodality characterization of microstructure by the combination of diffusion NMR and time-domain diffuse optical data
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0031-9155/59/11/2639
Publisher version: http://dx.doi.org/10.1088/0031-9155/59/11/263
Additional information: © 2014 Institute of Physics and Engineering in Medicine. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Keywords: Diffusion, Magnetic Resonance Spectroscopy, Markov Chains, Microtechnology, Monte Carlo Method, Optical Processes, Porosity
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: https://discovery.ucl.ac.uk/id/eprint/1415893
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