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Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture.

Allmendinger, R; Simaria, AS; Turner, R; Farid, SS; (2014) Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture. J Chem Technol Biotechnol , 89 (10) 1481 - 1490. 10.1002/jctb.4267. Green open access

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Abstract

This paper considers a real-world optimization problem involving the identification of cost-effective equipment sizing strategies for the sequence of chromatography steps employed to purify biopharmaceuticals. Tackling this problem requires solving a combinatorial optimization problem subject to multiple constraints, uncertain parameters, and time-consuming fitness evaluations.

Type: Article
Title: Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/jctb.4267
Publisher version: http://dx.doi.org/10.1002/jctb.4267
Additional information: ©� 2013 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: antibody purification technologies, biopharmaceutical manufacture, closed-loop optimization, downstream processing design, evolutionary computation, process economics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1413209
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