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Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M

Blondeau, C; Pelchen-Matthews, A; Mlcochova, P; Marsh, M; Milne, RS; Towers, GJ; (2013) Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M. Journal of Virology , 87 (24) pp. 13124-13133. 10.1128/JVI.02250-13. Green open access

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Abstract

Tetherin is a broadly active antiviral effector that works by tethering nascent enveloped virions to a host cell membrane, thus preventing their release. In this study, we demonstrate that herpes simplex virus 1 (HSV-1) is targeted by tetherin. We identify the viral envelope glycoprotein M (gM) as having moderate anti-tetherin activity. We show that gM but not gB or gD efficiently removes tetherin from the plasma membrane and can functionally substitute for the human immunodeficiency virus type 1 (HIV-1) Vpu protein, the prototypic viral tetherin antagonist, in rescuing HIV-1 release from tetherin-expressing cells. Our data emphasize that tetherin is a broadly active antiviral effector and contribute to the emerging hypothesis that viruses must suppress or evade an array of host cell countermeasures in order to establish a productive infection.

Type: Article
Title: Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/JVI.02250-13
Publisher version: http://dx.doi.org/10.1128/JVI.02250-13
Additional information: Copyright © 2013 Blondeau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
Keywords: Antigens, CD, Cell Membrane, GPI-Linked Proteins, Herpes Simplex, Herpesvirus 1, Human, Host-Pathogen Interactions, Humans, Membrane Glycoproteins, Protein Binding, Viral Proteins
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/1410700
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