Blondeau, C;
Pelchen-Matthews, A;
Mlcochova, P;
Marsh, M;
Milne, RS;
Towers, GJ;
(2013)
Tetherin restricts herpes simplex virus 1 and is antagonized by glycoprotein M.
Journal of Virology
, 87
(24)
pp. 13124-13133.
10.1128/JVI.02250-13.
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Abstract
Tetherin is a broadly active antiviral effector that works by tethering nascent enveloped virions to a host cell membrane, thus preventing their release. In this study, we demonstrate that herpes simplex virus 1 (HSV-1) is targeted by tetherin. We identify the viral envelope glycoprotein M (gM) as having moderate anti-tetherin activity. We show that gM but not gB or gD efficiently removes tetherin from the plasma membrane and can functionally substitute for the human immunodeficiency virus type 1 (HIV-1) Vpu protein, the prototypic viral tetherin antagonist, in rescuing HIV-1 release from tetherin-expressing cells. Our data emphasize that tetherin is a broadly active antiviral effector and contribute to the emerging hypothesis that viruses must suppress or evade an array of host cell countermeasures in order to establish a productive infection.
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