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Cysteine promoted c-terminal hydrazinolysis of native peptides and proteins

Adams, AL; Cowper, B; Morgan, RE; Premdjee, B; Caddick, S; Macmillan, D; (2013) Cysteine promoted c-terminal hydrazinolysis of native peptides and proteins. Angewandte Chemie International Edition , 52 (49) 13062- 13066. 10.1002/anie.201304997. Green open access

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Abstract

Tagging the terminus: N→S acyl transfer in native peptides and proteins can be reliably intercepted with hydrazine. The method allows selective labeling and ligation, without recourse to the use of protein-splicing elements. NCL=native chemical ligation.

Type: Article
Title: Cysteine promoted c-terminal hydrazinolysis of native peptides and proteins
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/anie.201304997
Publisher version: http://dx.doi.org/10.1002/anie.201304997
Language: English
Additional information: © 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Ccyl transfer, Erythropoietin, Hydrazides, Native chemical Ligation, Peptides
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1410151
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