Adams, AL;
Cowper, B;
Morgan, RE;
Premdjee, B;
Caddick, S;
Macmillan, D;
(2013)
Cysteine promoted c-terminal hydrazinolysis of native peptides and proteins.
Angewandte Chemie International Edition
, 52
(49)
13062- 13066.
10.1002/anie.201304997.
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Abstract
Tagging the terminus: N→S acyl transfer in native peptides and proteins can be reliably intercepted with hydrazine. The method allows selective labeling and ligation, without recourse to the use of protein-splicing elements. NCL=native chemical ligation.
| Type: | Article |
|---|---|
| Title: | Cysteine promoted c-terminal hydrazinolysis of native peptides and proteins |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/anie.201304997 |
| Publisher version: | http://dx.doi.org/10.1002/anie.201304997 |
| Language: | English |
| Additional information: | © 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Ccyl transfer, Erythropoietin, Hydrazides, Native chemical Ligation, Peptides |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1410151 |
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