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Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development.

Jones, A; Teschendorff, AE; Li, Q; Hayward, JD; Kannan, A; Mould, T; West, J; ... Widschwendter, M; + view all (2013) Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development. PLoS Med , 10 (11) , Article e1001551. 10.1371/journal.pmed.1001551. Green open access

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Abstract

Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of cancer. The objective of this study was to determine the functional role of epigenetic factors in endometrial cancer development.

Type: Article
Title: Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pmed.1001551
Publisher version: http://dx.doi.org/10.1371/journal.pmed.1001551
Additional information: ©� 2013 Jones et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/1410034
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