Sivaraman, V;
Yellon, DM;
(2014)
Pharmacologic Therapy That Simulates Conditioning for Cardiac Ischemic/Reperfusion Injury.
J Cardiovasc Pharmacol Ther
, 19
(1)
pp. 83-96.
10.1177/1074248413499973.
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Abstract
Cardiovascular disease remains a leading cause of deaths due to noncommunicable diseases, of which ischemic heart disease forms a large percentage. The main therapeutic strategy to treat ischemic heart disease is reperfusion that could either be medical or surgical. However, reperfusion following ischemia is known to increase the infarct size further. Newer strategies such as ischemic preconditioning (IPC), ischemic postconditioning, and remote IPC have been shown to condition the myocardium to ischemia-reperfusion injury and thus reduce the final infarct size. Research over the past 3 decades has deepened our understanding of cellular and subcellular pathways that mediate ischemia-reperfusion injury. This in turn has resulted in the development of several pharmacological agents that act as conditioning agents, which reduce the final myocardial infarct size following ischemia-reperfusion. This review discusses many of these agents, their mechanisms of action, and the animal and clinical evidence behind them.
| Type: | Article |
|---|---|
| Title: | Pharmacologic Therapy That Simulates Conditioning for Cardiac Ischemic/Reperfusion Injury. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1074248413499973 |
| Publisher version: | http://dx.doi.org/10.1177/1074248413499973 |
| Additional information: | © The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
| Keywords: | acute myocardial infarction, cardiac pharmacology, heart disease, ischemia–reperfusion injury |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1409039 |
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