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Developmental mapping of small conductance calcium-activated potassium channel expression in the rat nervous system.

Gymnopoulos, M; Cingolani, LA; Pedarzani, P; Stocker, M; (2014) Developmental mapping of small conductance calcium-activated potassium channel expression in the rat nervous system. Journal of Comparative Neurology , 522 (5) pp. 1072-1101. 10.1002/cne.23466. Green open access

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Abstract

Early electrical activity and calcium influx regulate crucial aspects of neuronal development. Small conductance calcium-activated potassium (SK) channels regulate action potential firing and shape calcium influx through feedback regulation in mature neurons. These functions, observed in the adult nervous system, make them ideal candidate to regulate activity- and calcium-dependent processes in neurodevelopment. However, to date little is known about the onset of expression and regions expressing SK channel subunits in the embryonic and postnatal development of the central nervous system. To enable studies on the contribution of SK channels to different phases of development of single neurons and networks, we have performed a detailed in situ hybridization mapping study, providing comprehensive distribution profiles of all three SK subunits (SK1, SK2, and SK3) in the rat central nervous system during embryonic and postnatal development. SK channel transcripts are expressed at early stages of prenatal development of the central nervous system. The three SK channel subunits display different developmental expression gradients in distinct central nervous system regions, with time-points of expression and up- or down-regulation that can be associated to a range of diverse developmental events. Their early expression in embryonal development suggests an involvement of SK channels in the regulation of developmental processes. Additionally, this study shows how the postnatal ontogenetic patterns lead to the adult expression map for each SK channel subunit, and how their co-expression in the same regions or neurons varies throughout development. J. Comp. Neurol., 2013.

Type: Article
Title: Developmental mapping of small conductance calcium-activated potassium channel expression in the rat nervous system.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cne.23466
Publisher version: http://dx.doi.org/10.1002/cne.23466
Language: English
Additional information: © 2013 Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: SK channel, SK1, SK2 and SK3 ontogenesis, afterhyperpolarizing current, apamin, embryonal and postnatal distribution, in situ hybridization
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1409007
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