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Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays

Soreq, L; Gilboa-Geffen, A; Berrih-Aknin, S; Lacoste, P; Darvasi, A; Soreq, E; Bergman, H; (2008) Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays. PLoS ONE , 3 (6) , Article e2392. 10.1371/journal.pone.0002392. Green open access

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Abstract

The vast majority of human genes (>70%) are alternatively spliced. Although alternative pre-mRNA processing is modified in multiple tumors, alternative hyper-splicing signatures specific to particular tumor types are still lacking. Here, we report the use of Affymetrix Human Exon Arrays to spot hyper-splicing events characteristic of myasthenia gravis (MG)-thymoma, thymic tumors which develop in patients with MG and discriminate them from colon cancer changes.

Type: Article
Title: Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0002392
Publisher version: http://dx.doi.org/10.1371/journal.pone.0002392
Language: English
Additional information: © 2008 Soreq et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1408323
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