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Small molecule stimulation enhances bone regeneration but not titanium implant osseointegration

Gellynck, K; Shah, R; Parkar, M; Young, A; Buxton, P; Brett, P; (2013) Small molecule stimulation enhances bone regeneration but not titanium implant osseointegration. Bone , 57 (2) pp. 405-412. 10.1016/j.bone.2013.09.012. Green open access

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Abstract

Abstract The osteogenic and osseointegrative potential of a small molecule was examined to assess its usefulness in regenerative procedures. Purmorphamine was used to stimulate bone growth and repair in an in vitro cell based assay and an in vivo chick embryo CAM-assay with and without the presence of an implant. Purmorphamine adhered to precipitated hydroxyapatite coating, could activate the sonic hedgehog pathway and thereby stimulated osteodifferentiation. Porous calcium phosphate beads were used to deliver this small molecule in vivo and showed that purmorphamine increased the trabecular bone-to-bone area significantly. The assay showed Purmorphamine failed to induce any significant difference in osseointegration on titanium coated PTFE implants. This suggests that, whilst a small molecule can enhance osteogenesis and might be useful in regenerative procedures, it failed to enhance the osseointegration of a Ti coated implant, suggesting that this sort of stimulation might be useful for enhancing bone regeneration where bone loss due to disease exists, but not for enhancing early stability of an implant.

Type: Article
Title: Small molecule stimulation enhances bone regeneration but not titanium implant osseointegration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bone.2013.09.012
Publisher version: http://dx.doi.org/10.1016/j.bone.2013.09.012
Language: English
Additional information: © 2013 The Authors. Published by Elsevier Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: bone hedgehog pathway purmorphamine calcium phosphate osseointegration titanium implant regeneration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1407377
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