Mauguen, A;
Pignon, JP;
Burdett, S;
Domerg, C;
Fisher, D;
Paulus, R;
Mandrekar, SJ;
... Surrogate Lung Project Collaborative Group; + view all
(2013)
Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data.
Lancet Oncology
, 14
(7)
619 - 626.
10.1016/S1470-2045(13)70158-X.
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Abstract
The gold standard endpoint in clinical trials of chemotherapy and radiotherapy for lung cancer is overall survival. Although reliable and simple to measure, this endpoint takes years to observe. Surrogate endpoints that would enable earlier assessments of treatment effects would be useful. We assessed the correlations between potential surrogate endpoints and overall survival at individual and trial levels.
| Type: | Article |
|---|---|
| Title: | Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S1470-2045(13)70158-X |
| Publisher version: | http://dx.doi.org/10.1016/S1470-2045(13)70158-X |
| Language: | English |
| Additional information: | Copyright © 2013 Elsevier Ltd. PMCID: PMC3732017 |
| Keywords: | Biological Markers, Carcinoma, Non-Small-Cell Lung, Chemoradiotherapy, Chemotherapy, Adjuvant, Humans, Lung Neoplasms, Prognosis, Radiotherapy, Adjuvant, Randomized Controlled Trials as Topic, Survival Rate |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1406787 |
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