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Quantification of microbubble concentration through x-ray phase contrast imaging

Millard, TP; Endrizzi, M; Rigon, L; Arfelli, F; Menk, RH; Owen, J; Stride, E; (2013) Quantification of microbubble concentration through x-ray phase contrast imaging. Applied Physics Letters , 103 (11) , Article 114105. 10.1063/1.4821277. Green open access

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Abstract

The use of microbubbles as a contrast agent for x-ray phase contrast imaging could both transform x-ray imaging into a “functional” modality and enable much needed monitoring of targeted drug delivery. To realize these benefits, it is essential to be able to quantify bubble concentration in a given tissue volume. We developed and validated a model that enables this to be achieved not only for phase-retrieved images obtained by processing multiple frames but also on “single-shot” images, a likely necessity in in-vivo implementations. Our experimental validation was based on analyzer-based imaging, but extension to other phase-based modalities is straightforward.

Type: Article
Title: Quantification of microbubble concentration through x-ray phase contrast imaging
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1063/1.4821277
Publisher version: http://dx.doi.org/10.1063/1.4821277
Language: English
Additional information: © 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters / Volume 103 / Issue 11 / INTERDISCIPLINARY AND GENERAL PHYSICS and may be found at http://apl.aip.org/resource/1/applab/v103/i11/p114105_s1
Keywords: x-ray imaging, phase contrast imaging, dark field imaging, microbubbles
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1405990
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