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Preparation of multicompartment sub-micron particles using a triple-needle electrohydrodynamic device.

Labbaf, S; Deb, S; Cama, G; Stride, E; Edirisinghe, M; (2013) Preparation of multicompartment sub-micron particles using a triple-needle electrohydrodynamic device. J Colloid Interface Sci , 409 pp. 245-254. 10.1016/j.jcis.2013.07.033. Green open access

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Abstract

Control over the size and morphology of polymeric carriers for drug delivery systems is essential to optimize their functionality. In the current study, we demonstrate the feasibility of using an electrohydrodynamic process with a triple-needle device to prepare nearly mono-dispersed, spherical, tri-layered sub-micron particles. Three biocompatible polymer solutions of poly (lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL) and polymethylsilsesquioxane (PMSQ) were used to prepare particles with three distinct layers. Optimized particles were shown to be spherical with an average size ranging from 320nm (±80nm) to 220 (±8nm), which varied with a change in the working distance in the electrohydrodynamic processing. The surface and internal structure and morphology were studied using confocal, transmission and scanning electron microscopy combined with focused ion beam sectioning. Cytotoxicity was shown to be negligible in an in vitro assay. The ability to fabricate such multilayered particles in a single step, under ambient conditions has considerable potential for a range of applications in particular controlled release drug delivery system.

Type: Article
Title: Preparation of multicompartment sub-micron particles using a triple-needle electrohydrodynamic device.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jcis.2013.07.033
Publisher version: http://dx.doi.org/10.1016/j.jcis.2013.07.033
Additional information: ©� 2013 Elsevier Inc. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Keywords: Drug delivery, Electrohydrodynamic, Human osteoblast cells, Multilayered structures, Polymer, Sub-micron particles
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Security and Crime Science
URI: https://discovery.ucl.ac.uk/id/eprint/1405322
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