Silberhumer, GR;
Gyoeri, G;
Kern, B;
Muehlbacher, F;
Berlakovich, GA;
Rahmel, A;
Karam, V;
... Burroughs, AK; + view all
(2013)
The difficulty in defining extended donor criteria for liver grafts: The Eurotransplant experience.
Transplant International
, 26
(10)
pp. 990-998.
10.1111/tri.12156.
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Abstract
Donor criteria for liver grafts have been expanded because of organ shortage. Currently, no exact definitions for extended donor grafts have been established. The aim of this study was to analyze the impact of donor-specific risk factors, independent of recipient characteristics. In collaboration with Eurotransplant and European Liver Transplant Register, solely donor-specific parameters were correlated with 1-year survival following liver transplantation. Analyses of 4701 donors between 2000 and 2005 resulted in the development of a nomogram to estimate graft survival for available grafts. Predictions by nomogram were compared to those by Donor Risk Index (DRI). In the multivariate analysis, cold ischemic time (CIT), highest sodium, cause of donor death, γ-glutamyl transferase (γ-GT), and donor sex (female) were statistically significant factors for 3 months; CIT, γ-GT, and cause of donor death for 12-month survival. The median DRI of this study population was 1.45 (Q1: 1.17; Q3: 1.67). The agreement between the nomogram and DRI was weak (kappa = 0.23). Several donor-specific risk factors were identified for early survival after liver transplantation. The provided nomogram will support quick organ quality assessment. Nevertheless, this study showed the difficulties of determining an exact definition of extended criteria donors. © 2013 Steunstichting ESOT.
| Type: | Article |
|---|---|
| Title: | The difficulty in defining extended donor criteria for liver grafts: The Eurotransplant experience |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/tri.12156 |
| Publisher version: | http://dx.doi.org/10.1111/tri.12156 |
| Additional information: | © 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd. Full text made available to UCL Discovery by kind permission of Wiley. |
| Keywords: | donor evaluation; extended liver donor criteria; liver transplantation; organ quality; |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1405043 |
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