Kelly-Irving, M;
Lepage, B;
Dedieu, D;
Bartley, M;
Blane, D;
Grosclaude, P;
Lang, T;
(2013)
Adverse childhood experiences and premature all-cause mortality.
European Journal of Epidemiology
, 28
(9)
721 - 734.
10.1007/s10654-013-9832-9.
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Abstract
Events causing stress responses during sensitive periods of rapid neurological development in childhood may be early determinants of all-cause premature mortality. Using a British birth cohort study of individuals born in 1958, the relationship between adverse childhood experiences (ACE) and mortality ≤50 year was examined for men (n = 7,816) and women (n = 7,405) separately. ACE were measured using prospectively collected reports from parents and the school: no adversities (70 %); one adversity (22 %), two or more adversities (8 %). A Cox regression model was carried out controlling for early life variables and for characteristics at 23 years. In men the risk of death was 57 % higher among those who had experienced 2+ ACE compared to those with none (HR 1.57, 95 % CI 1.13, 2.18, p = 0.007). In women, a graded relationship was observed between ACE and mortality, the risk increasing as ACE accumulated. Women with one ACE had a 66 % increased risk of death (HR 1.66, 95 % CI 1.19, 2.33, p = 0.003) and those with ≥2 ACE had an 80 % increased risk (HR 1.80, 95 % CI 1.10, 2.95, p = 0.020) versus those with no ACE. Given the small impact of adult life style factors on the association between ACE and premature mortality, biological embedding during sensitive periods in early development is a plausible explanatory mechanism.
Type: | Article |
---|---|
Title: | Adverse childhood experiences and premature all-cause mortality |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1007/s10654-013-9832-9 |
Publisher version: | http://dx.doi.org/10.1007/s10654-013-9832-9 |
Language: | English |
Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Premature mortality, Cohort study, Stress responses, Metabolic, Social environment, Health behaviour |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
URI: | https://discovery.ucl.ac.uk/id/eprint/1404763 |
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