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Modeling the physiological factors that affect drug delivery from a nipple shield delivery system to breastfeeding infants.

Gerrard, SE; Orlu-Gul, M; Tuleu, C; Slater, NK; (2013) Modeling the physiological factors that affect drug delivery from a nipple shield delivery system to breastfeeding infants. Journal of Pharmaceutical Sciences , 102 (10) 3773 - 3783. 10.1002/jps.23688. Green open access

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Abstract

An apparatus was designed to mimic lactation from a human breast. It was used to determine the influence of milk fat content and flow rate, and suction pulse rate of a breastfeeding infant upon the release of a model compound from a nipple shield delivery system (NSDS). The NSDS would be worn by a mother to deliver drugs and nutrients to her infant during breastfeeding. Sulforhodamine B dye (SB) was used as model compound and formulated as a dispersible tablet to be placed within the NSDS. Increasing suction pulse rate from 30 to 120 pulses/min clearly correlated with increased cumulative release of SB for the same volume of milk passed through the NSDS. No distinct correlation was found between flow rates (1, 5, and 8 mL/min) and SB release, possibly because of competing factors controlling release rate at different flow rates. A highly similar SB release rate into two fat content fluids (2.9 and 4.2 wt %) was observed for identical flow conditions. This proof of concept study outlines a novel method to mimic lactation from a breast, and future studies will lead to effective methods to identify key physiological factors that influence drug release from a NSDS.

Type: Article
Title: Modeling the physiological factors that affect drug delivery from a nipple shield delivery system to breastfeeding infants.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/jps.23688
Publisher version: http://dx.doi.org/10.1002/jps.23688
Language: English
Additional information: © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Controlled release/delivery; drug delivery systems; in vitro models; lactation; nipple shield delivery system; oral drug delivery; pediatric
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1402336
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