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Frontotemporal dementia

Warren, JD; Rohrer, JD; Rossor, MN; (2013) Frontotemporal dementia. BMJ , 347 , Article f4827. 10.1136/bmj.f4827. Green open access

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Abstract

Frontotemporal dementia refers to a diverse group of conditions that collectively are a major cause of young onset dementia Frontotemporal dementia produces selective brain atrophy involving the frontal and temporal lobes, requiring brain magnetic resonance imaging for accurate diagnosis Clinically, these diseases present chiefly as progressive aphasia or as disintegration of personality and behaviour that may be misdiagnosed as a psychiatric disorder Up to around a quarter of cases arise from dominant mutations in one of three major causative genes Frontotemporal dementia is commonly associated with other neurological impairment, in particular parkinsonism or motor neurone disease Treatment remains supportive, but patients and families need extensive counselling, future planning, and involvement of social and mental health services

Type: Article
Title: Frontotemporal dementia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bmj.f4827
Publisher version: http://dx.doi.org/10.1136/bmj.f4827
Language: English
Additional information: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/. PMCID: PMC3735339
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1401870
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