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Insights into ancient leprosy and tuberculosis using metagenomics

Donoghue, HD; (2013) Insights into ancient leprosy and tuberculosis using metagenomics. Trends in Microbiology , 21 (9) pp. 448-450. 10.1016/j.tim.2013.07.007. Green open access

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Abstract

Leprosy and tuberculosis were widespread in the past and remain significant diseases today. Comparison of ancient and modern genomes of Mycobacterium leprae and Mycobacterium tuberculosis gives insight into their evolution and a calibration of the timescale for observed changes. Recently, whole genome sequencing has revealed genotypes and mixed-strain infections.

Type: Article
Title: Insights into ancient leprosy and tuberculosis using metagenomics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tim.2013.07.007
Publisher version: http://dx.doi.org/10.1016/j.tim.2013.07.007
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Ancient DNA, Metagenomics, Microbial evolution, Mycobacterium leprae, Mycobacterium tuberculosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1401750
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