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Sexually dimorphic and sex-independent left-right asymmetries in chicken embryonic gonads

Intarapat, S; Stern, CD; (2013) Sexually dimorphic and sex-independent left-right asymmetries in chicken embryonic gonads. PLOS ONE , 8 (7) , Article e69893. 10.1371/journal.pone.0069893. Green open access

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Abstract

Female birds develop asymmetric gonads: a functional ovary develops on the left, whereas the right gonad regresses. In males, however, testes develop on both sides. We examined the distribution of germ cells using Vasa/Cvh as a marker. Expression is asymmetric in both sexes: at stage 35 the left gonad contains significantly more germ cells than the right. A similar expression pattern is seen for expression of ERNI (Ens1), a gene expressed in chick embryonic stem cells while they self-renew, but downregulated upon differentiation. Other pluripotency-associated markers (PouV/Oct3/4, Nanog and Sox2) also show asymmetric expression (more expressing cells on the left) in both sexes, but this asymmetry is at least partly due to expression in stromal cells of the developing gonad, and the pattern is different for all the genes. Therefore germ cell and pluripotency-associated genes show both sex-dependent and independent left-right asymmetry and a complex pattern of expression.

Type: Article
Title: Sexually dimorphic and sex-independent left-right asymmetries in chicken embryonic gonads
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0069893
Publisher version: http://dx.doi.org/10.1371/journal.pone.0069893
Language: English
Additional information: © 2013 Intarapat, Stern. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3716703
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1401675
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