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Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating brain energetics.

Moroz, T; Hapuarachchi, T; Bainbridge, A; Price, D; Cady, E; Baer, E; Tachtsidis, I; ... Cooper, CE; + view all (2013) Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating brain energetics. Adv Exp Med Biol , 789 339 - 344. 10.1007/978-1-4614-7411-1_45. Green open access

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Abstract

We have developed a computational model to simulate hypoxia-ischaemia (HI) in the neonatal piglet brain. It has been extended from a previous model by adding the simulation of carotid artery occlusion and including pH changes in the cytoplasm. Here, simulations from the model are compared with near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (MRS) measurements from two piglets during HI and short-term recovery. One of these piglets showed incomplete recovery after HI, and this is modelled by considering some of the cells to be dead. This is consistent with the results from MRS and the redox state of cytochrome-c-oxidase as measured by NIRS. However, the simulations do not match the NIRS haemoglobin measurements. The model therefore predicts that further physiological changes must also be taking place if the hypothesis of dead cells is correct.

Type: Article
Title: Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating brain energetics.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4614-7411-1_45
Publisher version: http://dx.doi.org/10.1007/978-1-4614-7411-1_45
Language: English
Additional information: © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Animals, Animals, Newborn, Brain, Carotid Arteries, Cerebrovascular Circulation, Disease Models, Animal, Electron Transport Complex IV, Energy Metabolism, Hemoglobins, Hydrogen-Ion Concentration, Hypoxia-Ischemia, Brain, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Oxygen Consumption, Spectroscopy, Near-Infrared, Swine
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1400802
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