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Reduction of cytochrome C oxidase during vasovagal hypoxia-ischemia in human adult brain: a case study

Ghosh, A; Kolyva, C; Tachtsidis, I; Highton, D; Elwell, CE; Smith, M; (2013) Reduction of cytochrome C oxidase during vasovagal hypoxia-ischemia in human adult brain: a case study. Advances in Experimental Medicine and Biology , 789 21 - 27. 10.1007/978-1-4614-7411-1_4. Green open access

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Abstract

Near-infrared spectroscopy (NIRS)-derived measurement of oxidized cytochrome c oxidase concentration ([oxCCO]) has been used as an assessment of the adequacy of cerebral oxygen delivery. We report a case in which a reduction in conscious level was associated with a reduction in [oxCCO]. Hypoxaemia was induced in a 31-year-old, healthy male subject as part of an ongoing clinical study. Midway through the hypoxaemic challenge, the subject experienced an unexpected vasovagal event with bradycardia, hypotension and reduced cerebral blood flow (middle cerebral artery blood flow velocity decrease from 70 to 30 cm s(-1)) that induced a brief reduction in conscious level. An associated decrease in [oxCCO] was observed at 35 mm (-1.6 μM) but only minimal change (-0.1 μM) at 20-mm source-detector separation. A change in optical scattering was observed, but path length remained unchanged. This unexpected physiological event provides an unusual example of a severe reduction in cerebral oxygen delivery and is the first report correlating change in clinical status with changes in [oxCCO].

Type: Article
Title: Reduction of cytochrome C oxidase during vasovagal hypoxia-ischemia in human adult brain: a case study
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4614-7411-1_4
Publisher version: http://dx.doi.org/10.1007/978-1-4614-7411-1_4
Language: English
Additional information: © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Adult, Anoxia, Bradycardia, Brain, Cerebrovascular Circulation, Electron Transport Complex IV, Humans, Ischemia, Male, Oxygen, Peptides, Spectroscopy, Near-Infrared
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1399753
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