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Intact Memory for Irrelevant Information Impairs Perception in Amnesia

Barense, MD; Groen, IIA; Lee, ACH; Yeung, L-K; Brady, SM; Gregori, M; Kapur, N; ... Henson, RNA; + view all (2012) Intact Memory for Irrelevant Information Impairs Perception in Amnesia. Neuron , 75 (1) 157 - 167. 10.1016/j.neuron.2012.05.014. Green open access

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Abstract

Memory and perception have long been considered separate cognitive processes, and amnesia resulting from medial temporal lobe (MTL) damage is thought to reflect damage to a dedicated memory system. Recent work has questioned these views, suggesting that amnesia can result from impoverished perceptual representations in the MTL, causing an increased susceptibility to interference. Using a perceptual matching task for which fMRI implicated a specific MTL structure, the perirhinal cortex, we show that amnesics with MTL damage including the perirhinal cortex, but not those with damage limited to the hippocampus, were vulnerable to object-based perceptual interference. Importantly, when we controlled such interference, their performance recovered to normal levels. These findings challenge prevailing conceptions of amnesia, suggesting that effects of damage to specific MTL regions are better understood not in terms of damage to a dedicated declarative memory system, but in terms of impoverished representations of the stimuli those regions maintain.

Type: Article
Title: Intact Memory for Irrelevant Information Impairs Perception in Amnesia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2012.05.014
Publisher version: http://dx.doi.org/10.1016/j.neuron.2012.05.014
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1398984
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