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Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

Hutton, CA; Tognin, S; Riecher-Rössler, A; Meisenzahl, EM; Wood, SJ; Hutton, C; Borgwardt, SJ; ... Mechelli, A; + view all (2013) Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis. Psychological Medicine 10.1017/S0033291713000998. Green open access

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Abstract

Background: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. Method: We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thickness was examined in regions previously identified as sites of neuroanatomical alterations in UHR subjects, using voxel-based cortical thickness. Results: At baseline UHR subjects, compared with controls, showed reduced cortical thickness in the right parahippocampal gyrus (p<0.05, familywise error corrected). There were no significant differences in cortical thickness between the UHR subjects who later developed psychosis and those who did not. Conclusions: These data suggest that UHR symptomatology is characterized by alterations in the thickness of the medial temporal cortex. We did not find evidence that the later progression to psychosis was linked to additional alterations in cortical thickness, although we cannot exclude the possibility that the study lacked sufficient power to detect such differences.

Type: Article
Title: Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0033291713000998
Publisher version: http://dx.doi.org/10.1017/S0033291713000998
Language: English
Additional information: © Cambridge University Press 2013.The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/3.0/>. The written permission of Cambridge University Press must be obtained for commercial re-use.
Keywords: Cerebral cortex, Magnetic resonance imaging, Parahippocampal gyrus, Prodromal period, Schizophrenic psychoses, Voxel-based cortical thickness
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1395687
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