UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Mesenchymal stem cells as vectors for lung cancer therapy

Kolluri, KK; Laurent, GJ; Janes, SM; (2013) Mesenchymal stem cells as vectors for lung cancer therapy. Respiration , 85 (6) 443 - 451. 10.1159/000351284. Green open access

[thumbnail of Kolluri_Respiration.pdf]
Preview
PDF
Kolluri_Respiration.pdf

Download (1MB)

Abstract

Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies. Mesenchymal stem cells (MSCs) possess the ability to specifically home into tumours and their metastases. This property of MSCs could be exploited for the delivery of various anti-tumour agents directly into tumours. However, MSCs are not simple delivery vehicles but cells with active physiological process. This review outlines various agents which can be delivered by MSCs with substantial emphasis on TRAIL (tumour necrosis factor-related apoptosis-inducing ligand).

Type: Article
Title: Mesenchymal stem cells as vectors for lung cancer therapy
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000351284
Publisher version: http://dx.doi.org/10.1159/000351284
Language: English
Additional information: © 2013 S. Karger AG, Basel. This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 Unported license (CC BY 3.0) (www.karger.com/OA-license-WT), applicable to the online version of the article only.
Keywords: Apoptosis, Delivery vectors, Homing, Lung cancer, Mesenchymal stem cells, TRAIL
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1395318
Downloads since deposit
190Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item