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Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study.

Charidimou, A; Meegahage, R; Fox, Z; Peeters, A; Vandermeeren, Y; Laloux, P; Baron, JC; ... Werring, DJ; + view all (2013) Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study. J Neurol Neurosurg Psychiatry , 84 (6) 624 - 629. 10.1136/jnnp-2012-304434. Green open access

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Abstract

Small vessel disease (mainly hypertensive arteriopathy and cerebral amyloid angiopathy (CAA)) is an important cause of spontaneous intracerebral haemorrhage (ICH), a devastating and still poorly understood stroke type. Enlarged perivascular spaces (EPVS) are a promising neuroimaging marker of small vessel disease. Based on the underlying arteriopathy distributions, we hypothesised that severe centrum semiovale EPVS are more common in lobar ICH attributed to CAA than other ICH. We evaluated EPVS prevalence, severity and distribution, and their clinical-radiological associations.

Type: Article
Title: Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2012-304434
Publisher version: http://dx.doi.org/10.1136/jnnp-2012-304434
Language: English
Additional information: © 2014 by the BMJ Publishing Group Ltd. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/3.0/ PMCID: PMC3905629
Keywords: Amyloid, Cerebrovascular Disease, Clinical Neurology, MRI, Age Factors, Aged, Biological Markers, Cerebral Arterial Diseases, Cerebral Arteries, Cerebral Hemorrhage, Female, Humans, Logistic Models, Magnetic Resonance Imaging, Male, Neuroimaging, Retrospective Studies, Severity of Illness Index
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1395241
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