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ND-Track: Tractography utilising parametric models of white matter fibre orientation dispersion

Rowe, MC; Zhang, H; Alexander, DC; (2013) ND-Track: Tractography utilising parametric models of white matter fibre orientation dispersion. In: Proceedings of the 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine: discovery, innovation and application - advancing MR for improved health. (pp. 1546 - 1546). Green open access

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Abstract

This work develops a tractography algorithm to leverage fibre dispersion estimates derived from fitting parametric models of orientation dispersion to diffusion data. Tractography techniques are powerful tools to probe white matter (WM) connectivity non-invasively. Most current techniques follow a small number of discrete directions per voxel to identify WM connections. This approach addresses the limitation of traditional DTI-based tractography for regions with crossing fibres. However, it remains an oversimplification for regions with fanning and bending configurations, where the underlying fibre orientation distributions are continuous rather than discrete [2]. Following only a discrete set of directions in this case misrepresents the underlying anatomy and is likely to result in false negative connectivity estimates. Recent parameterized models of fibre dispersion represent such sub-voxel fibre architecture more realistically and provide more accurate estimates of dispersion than non-parametric techniques such as spherical deconvolution, which are vulnerable to noise [3]. Here, we present a new tractography algorithm, hereby referred to as ND-Track (Neurite Dispersion Tracking), that leverages directional information gathered from parametric models of dispersion. We investigate the advantages of tracking with dispersion measures on a simple phantom and in in-vivo data, tracking through the coronal radiata, a region known to exhibit a significant degree of fibre dispersion. We further demonstrate that this approach does not compromise the tracking of the WM pathways for which the standard technique works well.

Type: Proceedings paper
Title: ND-Track: Tractography utilising parametric models of white matter fibre orientation dispersion
Event: 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
Location: Salt Lake City, Utah, USA
Dates: 2013-04-20 - 2013-04-26
ISBN-13: 9781629931029
Open access status: An open access version is available from UCL Discovery
Publisher version: http://ismrm.org/13/
Language: English
Additional information: Article ID: 0773. © 2013 International Society for Magnetic Resonance in Medicine. Reproduced here with permission.
Keywords: Tractography, Dispersion
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1394774
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