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Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk

Lafont, E; Milhas, D; Teissié, J; Therville, N; Andrieu-Abadie, N; Levade, T; Benoist, H; (2010) Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk. PLoS One , 5 (10) , Article e13638. 10.1371/journal.pone.0013638. Green open access

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Abstract

Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the presence of zVAD-fmk, a broad-spectrum caspase inhibitor, Fas engagement can also trigger an alternative, non-apoptotic caspase-independent form of cell death, which is initiated by RIP1. Controversy exists as to the ability of caspase-10 to mediate cell death in response to FasL (CD95L or CD178). Herein, the role of caspase-10 in FasL-induced cell death has been re-evaluated.

Type: Article
Title: Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0013638
Publisher version: http://dx.doi.org/10.1371/journal.pone.0013638
Language: English
Additional information: © 2010 Lafont et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC2964310
Keywords: Amino Acid Chloromethyl Ketones, Antigens, CD95, Blotting, Western, Caspase 10, Caspase Inhibitors, Cell Death, Cysteine Proteinase Inhibitors, Flow Cytometry, HeLa Cells, Humans, Jurkat Cells, Signal Transduction
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1394553
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