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Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease.

Preziosi, G; Raptis, DA; Raeburn, A; Thiruppathy, K; Panicker, J; Emmanuel, A; (2013) Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease. European Journal of Gastroenterology & Hepatology , 25 (9) 1044 - 1050. 10.1097/MEG.0b013e328361eaf8. Green open access

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Abstract

Bowel and bladder symptoms are highly prevalent in patients with multiple sclerosis (MS). Bladder dysfunction (affecting 75% of these patients) is caused by disease in the spinal cord, whilst the pathophysiology of bowel dysfunction is unknown. Pathways regulating both the organs lie in close proximity to the spinal cord, and coexistence of their dysfunction might be the result of a common pathophysiology. If so, the prevalence of bladder symptoms should be greater in patients with MS and bowel symptoms. This hypothesis is tested in the study. We also evaluated how patient-reported symptoms quantify bowel dysfunction.

Type: Article
Title: Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MEG.0b013e328361eaf8
Publisher version: http://dx.doi.org/10.1097/MEG.0b013e328361eaf8
Language: English
Additional information: © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Disability Evaluation, Female, Gastrointestinal Diseases, Gastrointestinal Tract, Humans, London, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Predictive Value of Tests, Prevalence, Questionnaires, Severity of Illness Index, Spinal Cord, Urinary Bladder, Urinary Bladder, Neurogenic
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/1393909
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