Siddall, HK;
Yellon, DM;
Ong, SB;
Mukherjee, UA;
Burke, N;
Hall, AR;
Angelova, PR;
... Hausenloy, DJ; + view all
(2013)
Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury.
PLoS One
, 8
(4)
, Article e62400. 10.1371/journal.pone.0062400.
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Abstract
Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute ischemia reperfusion injury (IRI) by preventing mitochondrial dysfunction.
| Type: | Article |
|---|---|
| Title: | Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0062400 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0062400 |
| Language: | English |
| Additional information: | © 2013 Siddall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by the British Heart Foundation grant number FS/06/023 and supported by researchers at the National Institute for Health Research University College London Hospitals Biomedical Research Centre. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1392403 |
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