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Edge illumination and coded-aperture X-ray phase-contrast imaging: Increased sensitivity at synchrotrons and lab-based translations into medicine, biology and materials science

Endrizzi, M; Diemoz, PC; Szafraniec, MB; Hagen, CK; Millard, TP; Zapata, CE; Munro, PRT; ... Olivo, A; + view all (2013) Edge illumination and coded-aperture X-ray phase-contrast imaging: Increased sensitivity at synchrotrons and lab-based translations into medicine, biology and materials science. In: Proceedings of Medical Imaging 2013: Physics of Medical Imaging. SPIE: Orlando, Florida. Green open access

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Abstract

The edge illumination principle was first proposed at Elettra (Italy) in the late nineties, as an alternative method for achieving high phase sensitivity with a very simple and flexible set-up, and has since been under continuous development in the radiation physics group at UCL. Edge illumination allows overcoming most of the limitations of other phase-contrast techniques, enabling their translation into a laboratory environment. It is relatively insensitive to mechanical and thermal instabilities and it can be adapted to the divergent and polychromatic beams provided by X-ray tubes. This method has been demonstrated to work efficiently with source sizes up to 100m, compatible with state-of-the-art mammography sources. Two full prototypes have been built and are operational at UCL. Recent activity focused on applications such as breast and cartilage imaging, homeland security and detection of defects in composite materials. New methods such as phase retrieval, tomosynthesis and computed tomography algorithms are currently being theoretically and experimentally investigated. These results strongly indicate the technique as an extremely powerful and versatile tool for X-ray imaging in a wide range of applications.

Type: Proceedings paper
Title: Edge illumination and coded-aperture X-ray phase-contrast imaging: Increased sensitivity at synchrotrons and lab-based translations into medicine, biology and materials science
Event: SPIE Medical Imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2007893
Publisher version: http://dx.doi.org/10.1117/12.2007893
Language: English
Additional information: © 2013 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1392354
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