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A Comparative Study of the Dentate Gyrus in Hippocampal Sclerosis in Epilepsy and Dementia.

Bandopadhyay, R; Liu, JY; Sisodiya, SM; Thom, M; (2014) A Comparative Study of the Dentate Gyrus in Hippocampal Sclerosis in Epilepsy and Dementia. Neuropathology and Applied Neurobiology , 40 (2) pp. 177-190. 10.1111/nan.12087. Green open access

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Abstract

Hippocampal Sclerosis (HS) is long-recognised in association with epilepsy (HSE ) and more recently in the context of cognitive decline or dementia in the elderly (HSD ), in some cases as a component of neurodegenerative diseases, including Alzheimer's disease (AD) and fronto-temporal lobe dementia (FTLD). There is an increased risk of seizures in AD and spontaneous epileptiform discharges in the dentate gyrus of transgenic AD models; epilepsy can be associated with an age-accelerated increase in AD-type pathology and cognitive decline. The convergence between these disease processes could be related to hippocampal pathology. HSE typically shows re-organisation of both excitatory and inhibitory neuronal networks in the dentate gyrus, and is considered to be relevant to hippocampal excitability. We sought to compare the pathology of HSE and HSD , focusing on re-organisation in the dentate gyrus.

Type: Article
Title: A Comparative Study of the Dentate Gyrus in Hippocampal Sclerosis in Epilepsy and Dementia.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12087
Publisher version: http://dx.doi.org/10.1111/nan.12087
Additional information: © 2013 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd 177 on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Hippocampal sclerosis, Hirano Bodies, NPY, calbindin, calretinin, dementia, epilepsy, granule cell dispersion, mossy fibre sprouting
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1391188
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