Cortes, E;
(2013)
Expression of IGF-1 splice variants in women’s reproductive system.
Doctoral thesis (PhD), UCL (University College London).
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Abstract
Studies in skeletal muscle following damage have demonstrated splicing of the insulin-like growth factor-1 gene to IGF-1Ea that is the source of mature IGF-I which is a main anabolic factor, IGF-1Eb,the function of which is not known and IGF-1Ec, known as Mechano Growth Factor (MGF). MGF increases the pool of muscle stem cells by activating them to proliferate. The aim of the thesis was to study expression of IGF-1 variants in female reproductive organs where cellular damage may lead to pathology: 1. The levator ani (LA) muscle: significant damage occurs following vaginal delivery and is a key element in pelvic floor physiology. LA samples from pre and post menopausal women were used as controls. 2. Ovarian tissue: repeated ovulations and failure of the epithelium to repair which may be a predisposing factor for ovarian cancer. 3. Myometrium: single monoclonal cellular damage may lead to abnormal proliferation of myometrium and may be a factor in the aetiology of uterine fibroids
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | PhD |
| Title: | Expression of IGF-1 splice variants in women’s reproductive system |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1390627 |
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