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A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II.

Shepherd, C; Liu, J; Goc, J; Martinian, L; Jacques, TS; Sisodiya, SM; Thom, M; (2013) A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II. Epilepsia , 54 (5) 898 - 908. 10.1111/epi.12143. Green open access

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Abstract

A diagnostic feature of focal cortical dysplasia (FCD) type II on magnetic resonance imaging (MRI) is increased subcortical white matter (WM) signal on T2 sequences corresponding to hypomyelination, the cause of which is unknown. We aimed to quantify WM pathology in FCD type II and any deficiency in the numbers and differentiation of oligodendroglial (OL) cell types within the dysplasia.

Type: Article
Title: A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/epi.12143
Publisher version: http://dx.doi.org/10.1111/epi.12143
Language: English
Additional information: © 2013 International League Against Epilepsy. Full text made available to UCL Discovery by kind permission of Wiley.
Keywords: 2',3'-Cyclic-Nucleotide Phosphodiesterases, Adolescent, Adult, Aged, Antigens, Antigens, CD45, Brain, Brain Diseases, Child, Female, Humans, Magnetic Resonance Imaging, Male, Malformations of Cortical Development, Middle Aged, Myelin Basic Protein, Myelin Proteins, Nerve Fibers, Myelinated, Nerve Tissue Proteins, Neural Pathways, Oligodendroglia, Proteoglycans, Receptor, Platelet-Derived Growth Factor alpha, Statistics, Nonparametric, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1389320
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