UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Drug-resistant tuberculosis: time for visionary political leadership

Abubakar, I; Zignol, M; Falzon, D; Raviglione, M; Ditiu, L; Masham, S; Adetifa, L; ... Zumla, A; + view all (2013) Drug-resistant tuberculosis: time for visionary political leadership. The Lancet Infectious Diseases , 13 (6) pp. 529-539. 10.1016/S1473-3099(13)70030-6. Green open access

[img]
Preview
Text
Abubakar_1-s2.0-S1473309913700306-main.pdf - Published version

Download (405kB) | Preview

Abstract

Two decades ago, WHO declared tuberculosis a global emergency, and invested in the highly cost-effective directly observed treatment short-course programme to control the epidemic. At that time, most strains of Mycobacterium tuberculosis were susceptible to first-line tuberculosis drugs, and drug resistance was not a major issue. However, in 2013, tuberculosis remains a major public health concern worldwide, with prevalence of multidrug-resistant (MDR) tuberculosis rising. WHO estimates roughly 630 000 cases of MDR tuberculosis worldwide, with great variation in the frequency of MDR tuberculosis between countries. In the past 8 years, extensively drug-resistant (XDR) tuberculosis has emerged, and has been reported in 84 countries, heralding the possibility of virtually untreatable tuberculosis. Increased population movement, the continuing HIV pandemic, and the rise in MDR tuberculosis pose formidable challenges to the global control of tuberculosis. We provide an overview of the global burden of drug-resistant disease; discuss the social, health service, management, and control issues that fuel and sustain the epidemic; and suggest specific recommendations for important next steps. Visionary political leadership is needed to curb the rise of MDR and XDR tuberculosis worldwide, through sustained funding and the implementation of global and regional action plans. This is the fifth in a Series of six papers about tuberculosis.

Type: Article
Title: Drug-resistant tuberculosis: time for visionary political leadership
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1473-3099(13)70030-6
Publisher version: http://dx.doi.org/10.1016/S1473-3099(13)70030-6
Language: English
Additional information: This article is available under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/).
Keywords: science & technology, life sciences & biomedicine, infectious diseases, infectious diseases, new-york-city, mycobacterium-tuberculosis, multidrug-resistance, treatment outcomes, mdr-tb, pulmonary tuberculosis, infection-control, european region, united-states, risk-factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/1389237
Downloads since deposit
36Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item