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Global gray matter changes in posterior cortical atrophy: a serial imaging study

Lehmann, M; Barnes, J; Ridgway, GR; Ryan, NS; Warrington, EK; Crutch, SJ; Fox, NC; (2012) Global gray matter changes in posterior cortical atrophy: a serial imaging study. Alzheimer's & Dementia , 8 (6) 502 - 512. 10.1016/j.jalz.2011.09.225. Green open access

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Abstract

Background: Posterior cortical atrophy (PCA) is a neurodegenerative condition predominantly associated with Alzheimer’s disease (AD) pathology. Cross-sectional imaging studies have shown different atrophy patterns in PCA patients compared with typical amnestic Alzheimer’s disease (tAD) patients, with greatest atrophy commonly found in posterior regions in the PCA group, whereas in the tAD group, atrophy is most prominent in medial temporal lobe regions. However, differential longitudinal atrophy patterns are not well understood. Methods: This study assessed longitudinal changes in brain and gray matter volumes in 17 PCA patients, 16 tAD patients, and 18 healthy control subjects. Both patient groups had symptom durations of approximately 5 years. Results: Progressive gray matter losses in both PCA and tAD patients were relatively widespread throughout the cortex, compared with control subjects, and were not confined to areas related to initial symptomatology. A multivariate classification analysis revealed a statistically significant group separation between PCA and tAD patients, with 72.7% accuracy (P < .01). Conclusion: Progression from an initially focal presentation to a more global pattern suggests that these different clinical presentations of AD might converge pathologically over time.

Type: Article
Title: Global gray matter changes in posterior cortical atrophy: a serial imaging study
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jalz.2011.09.225
Publisher version: http://dx.doi.org/10.1016/j.jalz.2011.09.225
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Posterior cortical atrophy; Magnetic resonance imaging; Longitudinal; Boundary shift integral; Voxel-based morphometry; Classification
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1389024
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