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NK cells: a double-edged sword in chronic hepatitis B virus infection.

Maini, MK; Peppa, D; (2013) NK cells: a double-edged sword in chronic hepatitis B virus infection. Front Immunol , 4 , Article 57. 10.3389/fimmu.2013.00057. Green open access

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Abstract

There is natural enrichment of NK cells in the human liver and this intrahepatic predominance underscores their potential importance in the control of infections with hepatotropic viruses such as hepatitis B virus (HBV). The contribution of innate components during chronic HBV infection has been a relatively under-investigated area. However, recent data have highlighted that NK cells are capable of exerting antiviral and immunoregulatory functions whilst also contributing to the pathogenesis of liver injury via death receptor pathways. We will present an overview of current knowledge regarding the complex biology of NK cells in the context of their antiviral versus pathogenic role in chronic hepatitis B as a clinically relevant avenue for further investigation.

Type: Article
Title: NK cells: a double-edged sword in chronic hepatitis B virus infection.
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fimmu.2013.00057
Publisher version: http://dx.doi.org/10.3389/fimmu.2013.00057
Language: English
Additional information: © 2013 Maini and Peppa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. PMCID: PMC3585438
Keywords: CD56bright, IFN-alfa, IL-10, NK cells, TRAIL, hepatitis B virus, interferon-gamma, liver damage
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1388379
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