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Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling.

Young, KM; Psachoulia, K; Tripathi, RB; Dunn, SJ; Cossell, L; Attwell, D; Tohyama, K; (2013) Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron , 77 (5) 873 - 885. 10.1016/j.neuron.2013.01.006. Green open access

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Abstract

Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood. It is not known whether adult-born OLs ensheath previously unmyelinated axons or remodel existing myelin. We quantified OP division and OL production in different regions of the adult mouse CNS including the 4-month-old optic nerve, in which practically all axons are already myelinated. Even there, all OPs were dividing and generating new OLs and myelin at a rate higher than can be explained by first-time myelination of naked axons. We conclude that adult-born OLs in the optic nerve are engaged in myelin remodeling, either replacing OLs that die in service or intercalating among existing myelin sheaths. The latter would predict that average internode length should decrease with age. Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life.

Type: Article
Title: Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2013.01.006
Publisher version: http://dx.doi.org/10.1016/j.neuron.2013.01.006
Language: English
Additional information: © 2013 Elsevier Inc. Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. PMCID: PMC3842597
Keywords: Aging, Animals, Cell Count, Cell Cycle, Cell Differentiation, Cell Division, Cell Survival, Central Nervous System, Immunohistochemistry, Mice, Mice, Transgenic, Microscopy, Confocal, Microscopy, Immunoelectron, Myelin Sheath, Oligodendroglia, Optic Nerve, Polymerase Chain Reaction, Receptor, Platelet-Derived Growth Factor alpha
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1388240
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