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Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice.

Nolan, LS; Maier, H; Hermans-Borgmeyer, I; Girotto, G; Ecob, R; Pirastu, N; Cadge, BA; ... Dawson, SJ; + view all (2013) Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice. Neurobiol Aging , 34 (8) 2077.e1 - 2077.e9. 10.1016/j.neurobiolaging.2013.02.009. Green open access

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Abstract

Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice.

Type: Article
Title: Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neurobiolaging.2013.02.009
Publisher version: http://dx.doi.org/10.1016/j.neurobiolaging.2013.02...
Language: English
Additional information: �© 2013 Elsevier Inc. All rights reserved. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
Keywords: Adult, Animals, Case-Control Studies, Cohort Studies, Ear, Inner, Female, Genetic Association Studies, Hearing, Hearing Loss, Humans, Male, Mice, Mice, Inbred C57BL, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Estrogen, Sex Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1388236
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