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Albuminuria is associated with too few glomeruli and too much testosterone

Long, DA; Kolatsi-Joannou, M; Price, KL; Dessapt-Baradez, C; Huang, JL; Papakrivopoulou, E; Hubank, M; ... Woolf, AS; + view all (2013) Albuminuria is associated with too few glomeruli and too much testosterone. Kidney International , 83 (6) 1118 -1129. 10.1038/ki.2013.45. Green open access

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Abstract

Normally, the glomerular filtration barrier almost completely excludes circulating albumin from entering the urine. Genetic variation and both pre- and postnatal environmental factors may affect albuminuria in humans. Here we determine whether glomerular gene expression in mouse strains with naturally occurring variations in albuminuria would allow identification of proteins deregulated in relatively 'leaky' glomeruli. Albuminuria increased in female B6 to male B6 to female FVB/N to male FVB/N mice, whereas the number of glomeruli/kidney was the exact opposite. Testosterone administration led to increased albuminuria in female B6 but not female FVB/N mice. A common set of 39 genes, many expressed in podocytes, were significantly differentially expressed in each of the four comparisons: male versus female B6 mice, male versus female FVB/N mice, male FVB/N versus male B6 mice, and female FVB/N versus female B6 mice. The transcripts encoded proteins involved in oxidation/reduction reactions, ion transport, and enzymes involved in detoxification. These proteins may represent novel biomarkers and even therapeutic targets for early kidney and cardiovascular disease.

Type: Article
Title: Albuminuria is associated with too few glomeruli and too much testosterone
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ki.2013.45
Publisher version: http://dx.doi.org/10.1038/ki.2013.45
Language: English
Additional information: his work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. PMCID: PMC3674403
Keywords: Albuminuria, Animals, Blood Pressure, Cells, Cultured, Female, Gene Expression Profiling, Gene Expression Regulation, Genotype, Glomerular Filtration Barrier, Kidney Glomerulus, Male, Mice, Mice, Inbred C57BL, Permeability, Phenotype, Podocytes, RNA, Messenger, Sex Factors, Species Specificity, Testosterone
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1388221
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